Objective To explore the application effect of gastric lavage fixed device in gastric lavage operation of emergency poisoning patients. Methods The improved device includes spiral mother bolt,buccal fixation belt,anti-suction side mouth,lip and tooth protective layer and the main body of the bite device,so as to solve the problems,such as gastric cleaning pipeline is difficult to be properly fixed,gastric reflux retention in the mouth,and lip skin damage. A total of 98 patients with poisoning and gastric lavage in the emergency department of a tertiary A hospital in Shenyang from December 2019 to December 2020 were enrolled as the research subjects. The patients were divided into an experimental group and a control group by random number table method,with 49 patients in each group. In the control group,the traditional mouthpiece device and human-assisted fixation method were used for gastric lavage,while in the experimental group,the improved fixed device of gastric lavage and lavage pipeline were used for gastric lavage. The number of displacement,extubation,tube bite,the time of gastric lavage and complications during gastric lavage were compared between the 2 groups. Results The number of displacement,extubation,tube bite,the time of gastric lavage and complications during gastric lavage in the experimental group were significantly lower than those in the control group,and the differences between the 2 groups were statistically significant（P<0.05）. Conclusion The fixed device of gastric lavage pipeline can effectively shorten gastric lavage time,save human resources,improve gastric lavage efficiency,reduce gastric lavage risks and reduce complications in gastric lavage operation of emergency poisoning patients.